Superantigen antagonist protects against lethal shock and defines a new domain for T-cell activation.
Arad G, Levy R, Hillman D, Kaempfer R. (2000) Nat Med. 6, 414-421.
Superantigen antagonist blocks Th1 cytokine gene induction and lethal shock.
Arad G, Hillman D, Levy R, Kaempfer R. (2001) J Leukoc Biol. 69, 921-927.
Superantigen concomitantly induces Th1 cytokine genes and the ability to shut off their expression on re-exposure to superantigen.
Arad G, Levy R, Kaempfer R. (2002) Immunol Lett. 82,75-78.
Defense against biologic warfare with superantigen toxins.
Kaempfer R, Arad G, Levy R, Hillman D. (2002) Isr Med Assoc J.520-3.
Biodefense strategies against superantigen toxins. In Terror and Medicine: Medical aspects of biological, chemical and radiological terrorism.
Kaempfer R, Arad G. (2003). (Shemer, J. and Shoenfeld, Y., Eds), Pabst Science Publishers, Lengerich, Germany, pp. 228-240.
Peptide antagonists of superantigen toxins.
Kaempfer R. (2003) Molec Diversity 8, 113-120.
Broad-spectrum immunity against superantigens is elicited in mice protected from lethal shock by a superantigen antagonist peptide.
Arad G, Hillman D, Levy R, Kaempfer R. (2004) Immunol Lett. 91, 141-5.
Israel's Atox aiming at inflammation in community acquired pneumonia, CAP-ping Inflammation.
Published on Monday, October 11, 2010, BioCentury on BioBusiness. Read More >>
Novel peptide antagonist therapy for superantigen and endotoxin-induced lethal shock.
Girish Ramachandran, Steven Opal, Melissa Whitford, Gila Arad, Raymond Kaempfer and Alan Cross International Endotoxin and Innate Immunity Society/Society of Leukocyte Biology, Vancouver, Canada, 2010. Read More >>
CD28 mimetic peptide treatment for superantigen- and endotoxin-induced lethal shock.
Alan Cross, Girish Ramachandran, Melissa Whitford, Gila Arad , Raymond Kaempfer and Steve Opal American Society of Microbiology, New Orleans, US, 2011. Read More >>
Binding of Superantigen Toxins into the CD28 Homodimer Interface Is Essential for Induction of Cytokine Genes That Mediate Lethal Shock.
Bacterial superantigens, a diverse family of toxins, induce an inflammatory cytokine storm that can lead to lethal shock. Read More >>
AB103, a CD28 antagonist peptide, a new therapeutic agent in model of severe sepsis .
Anat Shirvan, Chun-Shiang Chung, Alfred Ayala, Steve Opal, Abdullah Chahin and Dan Teleman, Sepsis 2011 Symposium . Read More >>